Best NAD+ Providers for Energy & Focus (2026), Ranked

Sorting and filtering change this table only — the ranked list below always keeps our published order. Prices and program details verified on each provider's own site in 2026 and can change without notice. Tru Niagen, Thorne, and Renue By Science are supplement retailers, so “clinician-reviewed” is correctly marked no — they ship an over-the-counter product, not a prescribed protocol. Confirm current terms with the provider before starting.

• Our #1 pick · $93 / month, flat

  1

  CoreAge Rx

  No human trial for this routeNasal spray + injection

  Visit CoreAge Rx — $93/mo flatDetails

  Nasal and injected NAD+ are marketed for cellular energy and focus with no rigorous human cognition or energy trial.

  Price: $93 / month, flat

  U.S.-licensed clinicians review an online intake; the NAD+ protocol is filled by a 503A compounding pharmacy. CoreAge markets the nasal spray (“Hello Energy”) and the injection both at a flat $93/month for cellular energy, focus, and bioavailability. Every plan includes 1:1 consults with a nurse and a registered dietitian, plus an automatic refund if you are not approved for treatment.

  Strengths

  • Transparent flat $93/month — same price for the nasal spray or the injection, no separate membership or lab fee
  • Doctor-reviewed protocols filled by a 503A compounding pharmacy
  • Included 1:1 support from a nurse and a registered dietitian
  • Automatic refund if you are not approved for treatment

  Trade-offs

  • Single-category focus — not a full hormone-optimization clinic
  • Like all compounded NAD+, it is not an FDA-approved product, and nasal NAD+ has no rigorous cognition trial (see our evidence review)

  Automatic refund if you are not approved · included nurse + dietitian consults. Verified on the provider’s own site in 2026.

• 2

  HealthRX

  From $134/mo

  No human trial for this routeSub-Q injection + nasal spray

  Visit HealthRXDetails

  Sub-Q and intranasal NAD+ sold for energy and focus; neither route has a rigorous human cognition trial behind it.

  Price: $161 / month injection (1,000 mg); $134 / month nasal spray

  A telehealth clinic that publishes its entire NAD+ price ladder in public rather than gating it behind an intake quiz. The self-administered sub-Q injection is dosed at 1,000 mg per month at $161; the nasal spray is $134. Both figures are all-in — the provider visit, unlimited follow-up messaging, injection supplies, and shipping sit inside the quoted price, with no membership or lab surcharge added later.

  Strengths

  • Full price ladder published up front, so you can compare it against CoreAge before handing over an email address
  • $161/mo injection and $134/mo nasal are the lowest clinician-supervised NAD+ rates on this board after our #1 pick
  • The provider visit, unlimited follow-ups, injection supplies, and shipping are all inside the quoted price — nothing is billed separately

  Trade-offs

  • Per-format pricing: the injection costs $27/month more than the nasal spray, so your all-in depends on which route you pick
  • Still roughly 1.4–1.7× CoreAge's flat $93, and the compounding pharmacy is not named the way CoreAge identifies its 503A facility
  • No nurse or registered-dietitian consults bundled — follow-ups are with the prescribing practice

  Shown for honest comparison — every figure above was verified on HealthRX’s own site in 2026 and can change without notice.

• 3

  RxSpan MD

  From $199/mo

  No human trial for this routeInjection, nasal spray, flex-dose tablet

  Visit RxSpan MDDetails

  Injected, nasal and oral NAD+ marketed for energy; no rigorous human trial supports any of the three routes for focus.

  Price: $249 / month injection or nasal spray; $199 / month flex-dose tablet

  A physician-led telehealth clinic whose longevity catalog carries NAD+ as an injection, a nasal spray, and an oral flex-dose tablet. The published monthly figure is what you actually pay: the clinician consult, the medication, injection supplies, and shipping are bundled into it, and the advertised rate is the month-to-month rate rather than a prepay tier quoted as a monthly equivalent.

  Strengths

  • The advertised price is the recurring price — no commitment tier or first-month promotion doing the work behind the headline
  • Consult, medication, supplies, and shipping bundled into one published monthly figure
  • Three routes, including a $199 oral flex-dose tablet for people who will not inject or spray

  Trade-offs

  • $249/month for the injection or nasal spray is roughly 2.7× CoreAge's flat $93
  • Per-format pricing — the tablet is $50/month cheaper than the two parenteral routes, so the all-in depends on your choice
  • No nurse or registered-dietitian support bundled, and the compounding pharmacy is not identified

  Shown for honest comparison — every figure above was verified on RxSpan MD’s own site in 2026 and can change without notice.

• 4

  Willow

  $199/mo flat

  No human trial for this routeSubcutaneous injection

  Visit WillowDetails

  Sold on “clearer thinking with less brain fog”, and Willow's own page states the therapy is not FDA-approved for these uses and has not been evaluated for safety or efficacy.

  Price: $199 / month, published on the public product page; HSA/FSA eligible

  Prescription-only telehealth: NAD+ is dispensed as a compounded subcutaneous injection prescribed by a licensed provider, and the price sits above the fold on the public product page rather than behind a quiz. Willow publishes the schedule up front — “Treatment begins at 3 times per week to help build NAD+ levels in the body. After the first month, patients may choose to continue at this frequency or transition to once-weekly dosing, with guidance from their Willow doctor.” The order ships as “a vial of NAD+ injectable solution, along with syringes and needles for administration.” Site-wide, Willow states it is not the compounding manufacturer, and it names no pharmacy.

  Strengths

  • A bare flat $199/month on the public product page — no “as low as”, no first-month promotion, and no intake to complete before the number is shown
  • Publishes the dosing schedule before you buy: three injections a week to start, then either the same frequency or once weekly after the first month, decided with a Willow doctor
  • Ships the vial with the syringes and needles to administer it, and the page is badged HSA/FSA eligible

  Trade-offs

  • The vial strength is never stated on the page, so $199 cannot be turned into a cost per milligram or compared against the programs here that publish a 1,000 mg monthly dose
  • Injection only — no nasal spray and no oral option, so there is nothing here for a reader who will not self-inject
  • Names no compounding pharmacy and no 503A/503B designation, stating only that it is not the compounding manufacturer

  Shown for honest comparison — every figure above was verified on Willow’s own site in 2026 and can change without notice.

• 5

  Enhance MD

  From $99/mo

  No human trial for this routeSub-Q injection + sublingual wafers

  Visit Enhance MDDetails

  Sublingual NAD+ absorption is unproven in humans, and neither the wafer nor the injection has a cognition trial behind it.

  Price: $199 / month injection; $99 / month sublingual wafers (month-to-month)

  Telehealth NAD+ as a self-administered sub-Q injection or a sublingual wafer, with the clinician consult inside the price and an automatic refund if the prescriber finds you are not an eligible candidate. The full ladder is public. Read it carefully: the “$169/mo” injection rate Enhance markets is a 12-month prepay. The month-to-month injection is $199 and the wafers are $99, and those are the figures quoted here.

  Strengths

  • $99/month sublingual wafers are the lowest clinician-supervised NAD+ price on this board
  • Consult included, plus an automatic refund if you are not approved — the same screening promise CoreAge makes
  • Full price ladder published rather than gated behind an intake quiz

  Trade-offs

  • The headline “$169/mo” injection rate requires a 12-month prepay — the real month-to-month price is $199, and that is what we quote
  • Per-format pricing: the injection costs twice the wafer, and sublingual absorption is the less plausible of the two routes
  • No nurse or registered-dietitian support bundled, and the compounding pharmacy is not named

  Shown for honest comparison — every figure above was verified on Enhance MD’s own site in 2026 and can change without notice.

• 6

  Sprout Health

  $249/mo

  No human trial for this routeSub-Q injection (kit included)

  Visit Sprout HealthDetails

  Injected NAD+ bypasses the gut, the more plausible route — it is still sold for energy with no human outcome trial.

  Price: $249 / month (injection kit, clinician evaluation, and overnight delivery included)

  A single-route program: a self-administered sub-Q NAD+ injection shipped as a complete kit, with a clinician evaluation and overnight delivery inside the price. There is no membership and no per-format surcharge to work around, because there is only one format. The “$199” shown in Sprout's marketing is a first-month promotional rate; the recurring price is $249, and that is the figure quoted here.

  Strengths

  • A single all-in monthly figure — no membership, starter fee, or per-format surcharge to discover later
  • The injection kit, clinician evaluation, and overnight shipping are all inside the price
  • True month-to-month: no commitment tier is required to reach the quoted rate

  Trade-offs

  • The advertised “$199” is a first-month promotion — the recurring rate is $249, roughly 2.7× CoreAge's flat $93
  • Injection only; there is no nasal or oral option if you will not self-inject
  • No nurse or registered-dietitian support bundled, and the compounding pharmacy is not identified

  Shown for honest comparison — every figure above was verified on Sprout Health’s own site in 2026 and can change without notice.

• 7

  System Labs

  $149/mo (first mo $89)

  No human trial for this routeInjection + nasal spray

  Visit System LabsDetails

  Injected and intranasal NAD+ sold for energy — the same two routes as our #1 pick, and the same absence of a rigorous human cognition trial behind either.

  Price: NAD+ lander publishes $149 struck through to $89 for the first month — a first-month teaser against the struck-through standing rate

  A compounded-telehealth catalog (NAD+ injection and nasal spray, sermorelin by injection and as an oral compound, glutathione, MIC+B12, GHK-CU cream, compounded GLP-1/GIP) operated by System Laboratories, Inc., with a LegitScript Certified badge on-site. Its NAD+ lander states $149 struck through to $89 for the first month and lists what comes with it: 20% off a Rythm blood test, injection supplies included, 2-day temperature-controlled shipping, and ongoing support from a real care team. Note the two URLs are different pages — the published figure is on the lander at systemlabs.com/lander/nad, while systemlabs.com/nad opens an intake questionnaire.

  Strengths

  • Sells NAD+ as an injection and as a nasal spray — the same two routes our #1 pick is ranked on, which no other program added to this board in 2026-07 offers
  • The lander names what sits inside the price: injection supplies, 2-day temperature-controlled shipping, ongoing support from a care team, and 20% off a Rythm blood test
  • Displays a LegitScript Certified badge rather than an unverified storefront claim

  Trade-offs

  • The published $89 is a first month, struck through from $149 — it is a promotional figure against a standing rate, not the rate you renew at
  • The price lives on a separate lander: the plain systemlabs.com/nad URL opens an intake questionnaire instead of a price, so which page you land on decides whether you see a number at all
  • NAD+ is one line in a wide compounded catalog that also runs sermorelin, glutathione, MIC+B12 and GLP-1/GIP — not a dedicated NAD+ program the way our #1 pick is

  Shown for honest comparison — every figure above was verified on System Labs’s own site in 2026 and can change without notice.

• 8

  Shed

  From $144/mo

  No human trial for this routeInjection (3×/week), nasal spray, oral tablets

  Visit ShedDetails

  Injection, nasal spray and oral tablets are all marketed for energy, with no human cognition trial behind any of the three.

  Price: $169 injection / $144 nasal spray / $169 oral tablets, per one-month supply

  Telehealth NAD+ in three routes — an injection dosed three times a week, a nasal spray, and oral tablets — each sold as an explicit one-month supply rather than a commitment tier. Headline prices are visible before you sign up, but the final figure is confirmed at the patient portal, and Shed does not publish whether the clinician consult is included in it.

  Strengths

  • Three routes at low headline prices — $144/month for the nasal spray is among the cheapest clinician-supervised rates here
  • Sold as a plain one-month supply, so nothing is locked behind a quarterly or annual prepay
  • Publishes a headline price at all, which several NAD+ telehealth programs still refuse to do

  Trade-offs

  • The final price is confirmed inside the patient portal, so the headline is an indication rather than a quote
  • Shed does not publish whether the clinician consult is included, so the true all-in cost is unknown until you are already in the funnel
  • No nurse or registered-dietitian support published, and the compounding pharmacy is not identified

  Shown for honest comparison — every figure above was verified on Shed’s own site in 2026 and can change without notice.

• 9

  MadeMed

  From $209/mo (3-mo min)

  No human trial for this routeSub-Q injection (1,000 mg/mo) + nasal spray

  Visit MadeMedDetails

  The same nasal and injected routes as our #1 pick, and the same gap behind them: no human cognition or energy trial.

  Price: No month-to-month plan. Injection $209/mo on a 3-month plan ($627) or $199/mo on 6 months ($1,194); nasal spray $279/mo on 3 months, $269/mo on 6

  MadeMed sells NAD+ as a nasal spray and a sub-Q injection — the same two routes CoreAge is ranked on — with the clinician consult included and every figure published rather than gated. What it does not sell is a single month: the injection is billed $627 per quarter ($209/mo) or $1,194 per six months ($199/mo), and the nasal spray $279/mo quarterly or $269/mo on six. A CMP blood panel is required before treatment, and MadeMed does not state that its cost is included.

  Strengths

  • Publishes the plan totals, not just a monthly-equivalent figure, so the real amount charged is visible before you start
  • Offers both routes our #1 pick offers, at a 1,000 mg/month injection dose
  • Requires a CMP blood panel before treatment — genuine screening rather than a rubber stamp

  Trade-offs

  • There is no month-to-month plan at all: the shortest commitment is three months at $627 up front, so the advertised “from $199/mo” is a six-month prepay
  • The required CMP blood panel's cost is not stated as included, so the true first payment cannot be worked out from the published page
  • At $269–279/month the nasal spray is the most expensive nasal NAD+ on this board — roughly 3× CoreAge's flat $93

  Shown for honest comparison — every figure above was verified on MadeMed’s own site in 2026 and can change without notice.

• 10

  Wellorithm

  $200/mo (first mo $150)

  No human trial for this routeInjection

  Visit WellorithmDetails

  A compounded NAD+ injection sold for energy; no rigorous human trial supports the injected route for focus or energy.

  Price: $150 first month, then $200/mo* — the asterisk reads “*Price shown applies to 500mg (2.5mL) 3-month plan paid upfront or with buy now, pay later programs. Actual price will depend on product and plan prescribed.”

  A facilitator-model telehealth brand selling a compounded NAD+ injection alongside sermorelin and compounded and branded GLP-1. The NAD+ page shows the product “In Stock” at $150 for a first month and then $200/mo, quoted as “Only $15/shot*, homekit included” with “Full-strength dosages”, “Compounded in the U.S.A”, and FSA/HSA eligibility, with a stated saving of up to $50 on a first order applied automatically at checkout. Wellorithm's own terms describe the arrangement plainly: it “acts as a facilitator, connecting users with licensed healthcare professionals through its Professional Entities. The company itself does not diagnose, treat, or practice medicine.”

  Strengths

  • Publishes a figure and its conditions on the public product page — $150 for a first month, then $200/mo, quoted as “Only $15/shot*, homekit included”
  • Ships a home kit with the prescription and states the compounding is done in the U.S.A.
  • FSA- and HSA-eligible, with the first-order discount stated to apply automatically at checkout rather than behind a code

  Trade-offs

  • The $200/mo applies to a 500 mg (2.5 mL) three-month plan paid upfront or financed, and the footnote adds that the actual price depends on the plan prescribed — so there is no month-to-month rate behind the headline
  • The compounding pharmacy is never named beyond “Compounded in the U.S.A”, and the terms describe Wellorithm itself as a facilitator that does not practice medicine
  • The site contradicts itself: the home page claims all 50 states while other pages say 49 (Louisiana excluded), the sermorelin page carries leftover NAD+ copy, and billing runs “every 28 days”, which is not a month

  Shown for honest comparison — every figure above was verified on Wellorithm’s own site in 2026 and can change without notice.

• 11

  yourEra

  From $249/mo (gated)

  No human trial for this routeRoute not published — “self-administered protocols”, format never named

  Visit yourEraDetails

  Sold for vitality, recovery and mental clarity — the clarity claim has no human trial behind it by any NAD+ route, named or unnamed.

  Price: Advertised from $249 / month, stated to include the provider evaluation, personalized protocol, medication and supplies, and ongoing check-ins; nothing beyond that entry figure is published outside the intake

  A physician-directed telehealth clinic selling NAD+ alongside GLP-1 and microdosing programs. Its NAD+ therapy is advertised “from $249/mo” with an unusually specific inclusion list — the provider evaluation, a personalized protocol, the medication and supplies, and ongoing check-ins are all stated to sit inside that figure, and the site claims the same price at every dose. What it never states is what you would be taking: the copy says only “self-administered protocols designed by your clinician”, and the product photography shows a compounded vial. Injection is implied; it is not published. Everything past the entry figure is behind intake.yourera.com.

  Strengths

  • Publishes what the price includes — evaluation, protocol, medication, supplies, and ongoing check-ins — which the other two gated programs here never do
  • States the same price at every dose, so a titration should not quietly raise the monthly figure
  • A licensed clinician decides whether a prescription is appropriate, and the program is built around tracked check-ins rather than a one-time script

  Trade-offs

  • The delivery route is never published: “self-administered protocols” plus a vial in the photography implies an injection, and we will not print a route the provider itself declines to state
  • $249 is an entry figure — the ladder above it sits behind the intake at intake.yourera.com, so the price you would actually pay is not knowable from the public site
  • At $249/month it is roughly 2.7× CoreAge's flat $93, and no nurse or registered-dietitian support is bundled

  Shown for honest comparison — every figure above was verified on yourEra’s own site in 2026 and can change without notice.

• 12

  Care Bare Rx

  From $199/mo (gated)

  No human trial for this routeRoute not published — “fast-acting or daily options” only

  Visit Care Bare RxDetails

  Marketed for energy, focus and mood at the cellular level without naming a route — and no NAD+ route has a rigorous human cognition trial.

  Price: Advertised “NAD+ THERAPY From $199/mo” on the home page only; the NAD+ product page publishes no price at all, and everything past that headline is behind a 6-step intake

  Telehealth NAD+ from a general-wellness brand that also sells weight-loss, hair and sexual-health medications: you submit an online intake, a licensed provider reviews it within 24 hours, and the prescription ships if you are approved. The home page advertises NAD+ therapy “From $199/mo”. The NAD+ product page carries the line “Transparent pricing, no insurance required” and then shows no price whatsoever — the real figure, whether the consult is inside it, and which of the “fast-acting or daily options” you would receive all appear only after a six-step intake that collects your name, email and sex before it quotes anything.

  Strengths

  • A licensed provider reviews the intake within 24 hours and the prescription ships only if you are approved
  • Two NAD+ options are offered — a fast-acting and a daily one — rather than a single fixed protocol
  • FSA- and HSA-eligible, with no insurance billed

  Trade-offs

  • The product page claims “Transparent pricing” while showing no price at all; the only figure published anywhere is the “From $199/mo” on the home page
  • The real price, the inclusions and the format are all behind a six-step intake that asks for your name, email and sex before it will quote you
  • Nothing states whether the clinician consult is inside the $199, so the all-in cost cannot be worked out until you are already in the funnel

  Shown for honest comparison — every figure above was verified on Care Bare Rx’s own site in 2026 and can change without notice.

• 13

  Bodybuilding Health+

  From $129/mo (gated)

  No human trial for this routeRoute not published — no format stated for the NAD+ line

  Visit Bodybuilding Health+Details

  Sold explicitly on “cognitive clarity” — the one claim no NAD+ route, including our own #1 pick's, has a human trial to support.

  Price: Advertised “NAD+ Starting at $129/mo”; no ladder, renewal terms or inclusions published — the real figure is set inside a height-and-weight quiz

  The compounded-telehealth arm of the Bodybuilding.com brand, operated by Dynamo Group LLC. Its Longevity & Optimization program lists NAD+ next to sermorelin at “Starting at $129/mo”, sold on energy support, cognitive clarity and healthy-aging protocols. That sentence is the entire published pricing: there is no dose ladder, no renewal term and no statement of what the figure includes. The real number is produced by a quiz at start.bbhealthplus.com that opens by asking your height and weight. The same page states a route for sermorelin — “available in injection or tablet” — and states none for NAD+.

  Strengths

  • $129 is the lowest headline figure on this board after our #1 pick's flat $93
  • Displays a LegitScript certification badge and runs under an established consumer brand rather than an anonymous storefront
  • Provider-guided and prescribed online, with NAD+ sold inside a defined longevity program rather than as a one-off add-on

  Trade-offs

  • “Starting at $129” is all there is — no dose ladder, no renewal terms, and no statement of what the price includes
  • The real figure only appears after a height-and-weight quiz, and that quiz opens with a “$150 off your first month” banner, so whatever it quotes, the first month and the recurring rate are not the same number
  • The NAD+ line names no delivery route at all, on a page that states the format for its sermorelin line — which makes the omission a choice rather than an oversight

  Shown for honest comparison — every figure above was verified on Bodybuilding Health+’s own site in 2026 and can change without notice.

• Not currently a paid partner — shown for honest comparison, same evidence standard applied

• 14

  AgelessRx

  From $185/mo

  No human trial for this routeInjection, nasal spray, transdermal patch

  Visit AgelessRxDetails

  No peer-reviewed human trial shows that intranasal or transdermal NAD+ raises cellular NAD+ at all.

  Price: Injection from $185–235/mo; nasal from $125; patch from $160

  A U.S. longevity-telehealth clinic with a real questionnaire → video → prescriber-review flow and a broad Rx menu (NAD+, plus metformin, LDN, and rapamycin). NAD+ is offered as a self-administered injection, an intranasal spray, or a battery-powered iontophoresis patch, marketed for energy and healthy aging. Cash-pay only, no insurance.

  Strengths

  • Among the most credible longevity-telehealth operators — genuine licensed-prescriber review, not a rubber stamp
  • Widest NAD+ menu here (injection, nasal, and active iontophoresis patch) so you can match the format to your preference
  • Injection plans start around $185/mo — closer to CoreAge than the IV-clinic crowd

  Trade-offs

  • Cash-only with a 'longevity Rx' framing; no nurse or registered-dietitian consults bundled like CoreAge
  • Its nasal and patch absorption claims are unproven — no peer-reviewed human trial shows intranasal or transdermal NAD+ raises cellular NAD+
  • Per-format pricing means your all-in cost depends on which delivery you pick

  Shown for honest comparison — every figure above was verified on AgelessRx’s own site in 2026 and can change without notice.

• 15

  Hone Health

  ~$190/mo

  No human trial for this routeInjection

  Visit Hone HealthDetails

  A self-administered injection is the more plausible NAD+ route, but no human cognition or energy trial supports it.

  Price: Injection $165/mo + $25/mo membership (~$190)

  A well-funded ($33M Series A, Jan 2025) telehealth clinic centered on men's hormone optimization, with good doctor reviews and a legitimate prescriber flow. NAD+ is offered as a self-administered injection — an add-on to its core TRT-style catalog rather than the hero product.

  Strengths

  • Real, well-capitalized clinic with solid prescriber reviews
  • Self-administered injection bypasses the gut, the more plausible NAD+ route

  Trade-offs

  • Stacked fees — the medication, a consult, and a $25/mo membership add up to roughly $190 vs CoreAge's flat $93
  • TRT-centric: NAD+ is an add-on, not a dedicated program, and no nurse/dietitian support is bundled
  • Membership-plus-medicine billing draws complaints about the true ongoing cost

  Shown for honest comparison — every figure above was verified on Hone Health’s own site in 2026 and can change without notice.

• 16

  Invigor Medical

  From $340/mo

  No human trial for this routeInjection + oral

  Visit Invigor MedicalDetails

  Injectable and oral NAD+ marketed to boost energy and support cognition, with no outcome trial behind either claim.

  Price: Starting at $340 / month (includes doctor consult and supplies)

  A 100%-online clinic (“prescribed by U.S. doctors”) that ships NAD+ injection or oral NAD+ to your door with the doctor consult and supplies bundled into the price. Invigor markets NAD+ to boost energy and support cognition. A starter fee and first-month promotions can apply.

  Strengths

  • Consult and supplies bundled into the advertised price
  • Long-running telehealth catalog with both injectable and oral NAD+ options

  Trade-offs

  • Starting price ($340/month) is the highest in this comparison and well above CoreAge's flat $93
  • Starter fee and shifting first-month promotions make the true ongoing cost harder to pin down
  • No included nurse or registered-dietitian support

  Shown for honest comparison — every figure above was verified on Invigor Medical’s own site in 2026 and can change without notice.

• 17

  Tru Niagen

  $49 (oral)

  Human trials on the moleculeOral (300mg Niagen NR capsule; also stick packs)

  Visit Tru NiagenDetails

  Multiple human RCTs show patented Niagen NR meaningfully raises blood NAD+ — none of them show sharper focus.

  Price: $49 / 30ct (~$39 on subscription)

  A supplement, not a telehealth program. Tru Niagen (ChromaDex) delivers 300mg of patented Niagen nicotinamide riboside (NR) daily, the most clinically studied NAD+ precursor. It is Alkemist Assured third-party verified, with higher-dose and stick-pack formats NSF Certified for Sport. You buy it directly — no intake, no clinician, no prescription.

  Strengths

  • Strongest evidence in the category — multiple human RCTs show NR meaningfully raises blood NAD+
  • Genuinely third-party verified (Alkemist Assured; NSF Certified for Sport on some formats) — ChromaDex's own 2025 study found 87% of competitor NR products failed label claims while Niagen passed
  • Lowest entry price here and no consult to schedule — just buy the bottle

  Trade-offs

  • An over-the-counter supplement with no clinician review, candidate screening, or prescribed protocol
  • Raising blood NAD+ is not the same as improving cognition or energy — no rigorous trial shows NR sharpens focus
  • Premium per-dose price and aggressive 'clinically proven' marketing; no nurse or dietitian support

  Shown for honest comparison — every figure above was verified on Tru Niagen’s own site in 2026 and can change without notice.

• 18

  Thorne (NiaCel 400)

  Pricing varies

  Human trials on the moleculeOral (NiaCel 400 — ~415mg NR malate capsule)

  Visit Thorne (NiaCel 400)Details

  NR is the best-evidenced NAD+ precursor in humans, but the trials used patented Niagen, not the NR-malate form here.

  Price: Pricing varies (~mid-range across retailers)

  Thorne is a practitioner-favored supplement brand known for broad third-party certification. NiaCel 400 supplies roughly 415mg of nicotinamide riboside (as NR malate) per serving and is NSF Certified for Sport. Like all supplements here, you buy directly — there is no intake, clinician review, or prescription.

  Strengths

  • Trusted, widely third-party-certified brand; NiaCel 400 is NSF Certified for Sport
  • Uses NR, the best-evidenced precursor for raising NAD+, at a generous per-serving dose

  Trade-offs

  • Over-the-counter supplement — no clinician oversight or candidate screening
  • Pricing is opaque and varies across retailers; the NR-malate form differs from the patented Niagen used in trials
  • Higher blood NAD+ does not equal proven cognitive or energy benefit; no nurse/dietitian support

  Shown for honest comparison — every figure above was verified on Thorne (NiaCel 400)’s own site in 2026 and can change without notice.

• 19

  Renue By Science

  $84.95 (oral)

  No human trial for this routeOral (liposomal capsules, sublingual)

  Visit Renue By ScienceDetails

  Oral liposomal NAD+/NMN bioavailability is debated and, like nasal NAD+, lacks rigorous cognition outcome trials.

  Price: NAD+ Complete (liposomal) $84.95; NMN from ~$40

  A supplement retailer, not a telehealth provider. Renue sells liposomal NAD+ and NMN capsules and sublingual tabs marketed for cellular energy and healthy aging, with an emphasis on liposomal bioavailability. You buy directly — there is no intake, no clinician review, and no prescription.

  Strengths

  • Lowest entry price and no consult to schedule — just buy the bottle
  • Oral option for people who do not want an injection or nasal spray

  Trade-offs

  • No clinician review or candidate screening — it is an over-the-counter supplement, not a prescribed protocol
  • Oral NAD+/NMN bioavailability is debated and, like nasal NAD+, lacks rigorous cognition outcome trials
  • No nurse or dietitian support; you are on your own for dosing and questions

  Shown for honest comparison — every figure above was verified on Renue By Science’s own site in 2026 and can change without notice.

Prices and formats are each provider's own published figures, verified in 2026 and subject to change. Providers we have no commercial tie to are linked with plain referral attribution rather than a paid link. Read the NAD+ evidence review before you buy anything here.