Route comparison
NAD+ nasal spray vs injection
For most buyers this is not a choice between two companies — it is a choice inside one. On our ranking, every one of the 13 providers selling a NAD+ nasal spray also sells the injection — usually in the same program, at the same monthly price. Neither route has a human trial behind it for focus or memory.
What actually separates them
| Nasal spray | Injection | |
|---|---|---|
| Providers publishing a price | 13 | 29 |
| Lowest published price | $93/mo | $93/mo |
| Median published price | $185/mo | $199/mo |
| Human trial for focus or memory | None published | None published |
| Practical difference | No needle, no sharps disposal | The format most programs lead with |
Prices are each provider's own published figure. The full table, every provider and every route, is on what NAD+ costs.
The providers that sell both routes
Listed in our ranking order, not by price. Where a provider prices the two routes differently, the difference is in its own plan structure rather than in the route.
- CoreAge Rx$93/mo flat
- HealthRXFrom $134/mo
- RxSpan MDFrom $199/mo
- System Labs$149/mo (first mo $89)
- ShedFrom $144/mo
- Lttl$199/mo
- Pallas HealthFrom $189/mo (12-wk prepay)
- MadeMedFrom $209/mo (3-mo min)
- Breeze Meds$169/mo injection
- MyDrHank$199/mo (advertised $137)
- AgelessRxFrom $185/mo
- Eden$158 all-in, first mo
- CeliaRx$399/fill (no subscription)
What the evidence supports
The route argument is a pharmacokinetics argument, and pharmacokinetics is not efficacy. Oral precursors are the only NAD+ format with randomized placebo-controlled trials that measured thinking, and those trials found the blood marker rises while cognition stays flat. No published human study has measured a cognitive outcome after an intranasal or an injected dose at all.
That is the whole basis on which either route can be recommended for focus, and it is the same for both. Our evidence review walks the trials one by one; the nasal route in detail and the IV route cover the two claims people meet most often.
If you are buying either route
CoreAge Rx tops our ranking at $93/mo flat and sells the spray and the injection at the same price, which is the pattern most of this page describes. Compounded NAD+ is not an FDA-approved product and the cognition evidence is thin for every route — this is a note on what a program costs and includes.
A note on how we're funded. We want to be gentle and honest here: a few of the links on this page are affiliate or referral links handled through the Katalys network, and if you decide to start a treatment or buy a product through one, we may earn a commission — at no extra cost to you. What we write about any product, and the price you pay, are the same either way. You're welcome to read the whole story here.
Common questions
- Is a NAD+ nasal spray better than an injection?
- Neither route has a human trial showing it improves focus, memory or mental clarity, so there is no evidence base on which one can be called better for cognition. The differences that are real are practical: the spray needs no needle and no sharps disposal, the injection is the format most providers lead with, and the price is usually identical because the same company sells both inside one program.
- Do NAD+ providers charge more for injections than nasal sprays?
- Barely. Among providers publishing a price, nasal programs start at $93 a month (median $185, 13 providers) and injection programs at $93 (median $199, 29 providers). And every one of the 13 providers selling the spray also sells the injection, priced together.
- Does nasal NAD+ reach the brain better than an injection?
- That is the marketing claim for the nasal route and it is not settled. Intranasal delivery of some molecules does reach the brain along the olfactory pathway, but no published human study has measured brain NAD+ after a nasal dose, and none has measured a cognitive outcome for either route. The only human pharmacokinetic data on injected or infused NAD+ tracked blood chemistry, not thinking.
- Which NAD+ route has actual human trial evidence?
- Oral precursors — nicotinamide riboside and NMN. They have randomized placebo-controlled trials, and those trials found that blood NAD+ rises while measured cognition stays flat. That is the strongest evidence base of any route, and it is evidence of a biomarker moving, not of clearer thinking.
- Can you switch between nasal spray and injection?
- Usually, because it is the same prescriber and often the same monthly fee — every one of the 13 providers selling the spray also sells the needle. Whether a switch changes your bill depends on the provider's plan structure, which is the thing worth checking before you sign up rather than after.
Next: every provider selling a NAD+ nasal spray, the injection ranking, or the full provider ranking.