Synergy Rx NAD+ Review: $275 a Month, and Terms That May Vary It

Our own file on Synergy Rx used to say it published no price anywhere. That was wrong, and it is worth saying how it was wrong before anything else, because the same mistake is easy to repeat.

The record came from fetching synergyrx.co as text. Nothing priced came back. But the Longevity tab's figures ship in the served HTML, and the complete priced catalogue — every product, every term rung — is sitting in the site's own JavaScript bundle, unauthenticated, for anyone who opens it. A page that renders nothing to a text fetch is not a page with no prices. It is a page you have not read.

So here is what Synergy Rx actually charges, and then the reason we still rank it below companies with worse-looking numbers.

The ladder

The NAD+ injection is $275 a month, month to month. Commit and it descends properly: $525 for three months ($175/mo), $899 for six ($150/mo), $1,599 for twelve ($133/mo). Glutathione and sermorelin injections sit at $275 as well, and a B-12 methylcobalamin injection at $109.

Two things about that ladder deserve credit, and one of them is unusual enough to spell out.

First, the month-to-month rung exists and is stated. Across the providers we rank, a startling number publish only the twelve-month rung and print it with a "/mo" after it. Synergy publishes all four and lets you see which is which.

Second, the longevity ladder descends the way a ladder should — which is not true of Synergy's own weight-loss shelf. There, the compounded semaglutide "bundle" at three months works out at $249 a month against a $199 month-to-month rate. The bundle is more expensive than not bundling. We mention it because it is the same company's pricing logic, and because it means the word "bundle" carries no information here.

$275 is not cheap. It is the highest month-to-month NAD+ figure among the companies we are paid by, and roughly three times our top pick's flat monthly rate. What you are asked to weigh against that is a full published ladder and a longevity shelf — NAD+, sermorelin, glutathione, B-12 and PT-141 — rather than a single SKU.

The sentence that undoes the ladder

Synergy's terms contain this, verbatim: "the final charge to your credit card may fluctuate contingent upon the prescribed medication and the chosen pharmacy."

That is why a company publishing a complete four-rung price ladder sits where it does on our board rather than near the top of it. A published price is only worth what the seller's terms say it is worth, and Synergy has reserved the right to charge something else. It is not a hidden clause and it is not unique — but most operators who publish a ladder do not simultaneously disclaim it, and the ones we rank above Synergy either publish a firm number or tell you plainly what condition their number is attached to.

It gets sharper. Synergy's /about page advertises a "Money Back Guarantee". Its terms state that "medical consult fees are not subject to or eligible for a refund… all sales are final." Those are two of the company's own pages, and they say opposite things about the question a reader most wants answered. We are not going to adjudicate which one governs — that is the point. A guarantee that another page of the same site refuses is not a guarantee you can plan around.

Running alongside both: a "$100 welcome credit… no code needed" and a site-wide "2026 Promo Applied!" with no published terms anywhere, and a "Join 50,000+ SynergyRx patients" counter with nothing behind it.

Where it ships, and where it will not say

Where it operates. The terms say the service is "available to individuals located in certain states" and instruct you to contact customer service for the list. There is no list. Any claim you may have read that Synergy serves all fifty states is unsupported by anything the company publishes, and we do not repeat it.

What does exist is per-product shipping exclusions, which are more specific and more useful: glutathione, B-12 and the compounded skin creams are not shipped to Alabama, Arkansas, Alaska, Connecticut, Indiana, Kentucky, Louisiana, Michigan, Minnesota, Vermont or Wisconsin. NAD+ is served in those eleven — but through secondary pharmacies, with Synergy's own copy noting that "cost may vary". So for roughly a fifth of the country, the published $275 is explicitly not the number.

What it does tell you, and why we got this wrong first time

An earlier version of this review said Synergy names no pharmacy and no clinician. That was false, and the mistake is worth showing rather than quietly fixing.

Synergy's homepage FAQ names four dispensing pharmacies with phone numbers — Belmar, Strive, Epiq Scripts and Casa Pharma Rx — and two prescribing physicians with their NPI numbers: Dr. Ana Lisa Carr, MD (NPI 1689841744) and Dr. Kelly Tenbrink, MD (NPI 1346482684), through the clinical group Lion MD. Both verify as active in the federal NPPES registry. Its `/about` page also publishes "Unlimited 24/7 Support Included… unlimited appointments, messaging and support".

The error was ours: a search that came up empty got written down as the provider being silent. A negative claim needs the same proof as a positive one, and "we could not find it" is not proof that it is not there. We have made this exact mistake on this site before, in the other direction — two companies were once recorded as publishing no price when both published $199.

But here is the qualifier, and it is the actual finding rather than a hedge. That disclosure is not Synergy's own writing. It is byte-identical to what its CareValidate siblings publish — the same four pharmacies, the same two physicians, in the same words. Breeze Meds, which we rank on the same board, names those four pharmacies and those two doctors too. So does Care Bare Rx, which adds two more clinicians.

That does not make it worthless — four named pharmacies and two verifiable NPIs are still four more and two more than most of this field offers. What it means is that finding the same bench on two brands is the platform, not agreement. If you are comparing Synergy against another CareValidate storefront and the doctors match, you have not found corroboration. You have found one source twice.

What it still will not tell you

Which of those four pharmacies fills your order. The names are published; the routing is not, and Synergy's own terms make the pharmacy a variable that can move the price.

What dose you get. No NAD+ or sermorelin strength is published anywhere, which is notable because Synergy's sibling brand on the same backend does publish a dose ladder. Synergy strips it. Without a milligram, $275 cannot be compared per unit against anything — which is the recurring hole in how NAD+ is priced across this category.

The PT-141 page, which tells you something about the whole catalogue

Synergy sells PT-141 at $275, and its product description reads: "PT-141 is a peptide that increases the body's natural production of growth hormone (GH)… increased lean muscle mass, decreased body fat, improved sleep."

That is not what PT-141 is. PT-141 — bremelanotide — is a melanocortin receptor agonist studied and marketed for sexual dysfunction. It is not a growth-hormone secretagogue and it does not do any of the things that sentence promises. The text is Synergy's sermorelin description, pasted onto the wrong molecule.

We name it rather than repeat it, and we raise it on a page about NAD+ for one reason: it is evidence about how the product copy on this site is produced. A catalogue where one product's description has been pasted onto another is a catalogue where the descriptions have not been read. That is worth knowing before trusting the NAD+ page's account of what NAD+ does — and it is the same failure another company we rank made, in the same direction, on its own NAD+ page describing a different molecule entirely.

There is a structural reason these errors travel. Synergy runs on the CareValidate platform, as do two other brands on our board. The product copy is byte-identical across them, so a mistake written once appears on several unrelated storefronts. It also means Synergy's clinicians, pharmacies and FAQ are not independent corroboration of anyone else's, and nobody should read three brands on one backend as three second opinions.

What checks out

Two things do, and both were resolved against the issuing source rather than taken off a badge.

LegitScript. Synergy's seal ID returns a live record from LegitScript's own server, verified against an invented control in the same pass.

The FDA warning-letter index is clean for this company. We screened "synergyrx", "synergy rx", "usable health", "careglp" and "carevalidate" and every one returned zero company matches, with a known positive control firing in the same pass so that the zeroes are a result rather than a broken query. The only "synergy" records in the index belong to a pet-products company and a tobacco processor — different companies, and we do not file them against this one.

The evidence, which does not move for a paying partner

No rigorous human trial shows that injected NAD+ improves cognition, focus or energy. That is our position for every company we rank, and it does not soften for one that pays us. In older adults with mild cognitive impairment, oral nicotinamide riboside raised NAD+ and did not improve cognition versus placebo¹; a second randomised trial in subjective cognitive decline and mild cognitive impairment found no cognitive benefit²; and the only human data on a parenteral route is a pilot that tracked NAD+ metabolites through a six-hour infusion and measured no cognitive outcome at all³.

The long version is in our review of the NAD+ cognition evidence, and the compounded preparations sold here are not FDA-approved products — a compounded drug is not a generic equivalent of an approved one⁴.

The bottom line

Synergy Rx publishes more than our own records credited it with, twice over: a genuine month-to-month rung at $275 with a ladder that descends to $133 on a year, on a longevity shelf that runs to five injectables — and four named pharmacies and two NPI-verified physicians that an earlier draft of this page wrongly said did not exist. Its LegitScript certification resolves and its enforcement record is clean.

Against that: its terms reserve the right to charge something other than the published figure, its /about page promises a refund its terms refuse, it will not say which states it serves or which of its four pharmacies fills a given order, it publishes no dose, and one of its product pages describes the wrong molecule. Its clinical disclosure is real but it is shared word for word with the other brands on its backend, so it is one source rather than an independent one. The ladder is real too. What it is worth depends on a sentence in the terms saying it might not be.