Injectable route · July 2026
NAD+ Injections, Compared on Price — and on Evidence
11 clinician-supervised programs sell a subcutaneous NAD+ injection you give yourself at home, at published prices from $93 to $340 a month. Each is ranked on what we can check: whether the price is published, whether the advertised number is what you are charged, and who reviews you first.
The part the ads leave out: no human trial shows that injected NAD+ improves focus, energy or cognition. Not one — including for the pick we are paid on. This page ranks providers, never an outcome. The honest version of “before and after” is here.
A note on how we're funded. We want to be gentle and honest here: a few of the links on this page are affiliate or referral links handled through the Katalys network, and if you decide to start a treatment or buy a product through one, we may earn a commission — at no extra cost to you. What we write about any product, and the price you pay, are the same either way. You're welcome to read the whole story here.
#1 · our pick
CoreAge Rx
Doctor-reviewed NAD+ nasal spray (“Hello Energy”) with flat pricing and built-in human support.
- Price
- $93 / month, flat
- Routes sold
- Nasal spray + injection
- Transparent flat $93/month — same price for the nasal spray or the injection, no separate membership or lab fee
- Doctor-reviewed protocols filled by a 503A compounding pharmacy
- Included 1:1 support from a nurse and a registered dietitian
- Automatic refund if you are not approved for treatment
Worth knowing: Single-category focus — not a full hormone-optimization clinic. Like all compounded NAD+, it is not an FDA-approved product, and nasal NAD+ has no rigorous cognition trial (see our evidence review).
Every other NAD+ injection we could price
Some of the providers here pay us, and that can influence placement — we would rather say so than let you infer it. Prices are quoted exactly as published, so a program that charges differently for the injection and the spray is shown doing that.
- #2
HealthRX
$161 / month injection (1,000 mg); $134 / month nasal spray
Sub-Q injection + nasal spray
- #3
RxSpan MD
$249 / month injection or nasal spray; $199 / month flex-dose tablet
Injection, nasal spray, flex-dose tablet
- #4
Enhance MD
$199 / month injection; $99 / month sublingual wafers (month-to-month)
Sub-Q injection + sublingual wafers
Before you sign up: The headline “$169/mo” injection rate requires a 12-month prepay — the real month-to-month price is $199, and that is what we quote
- #5
Sprout Health
$249 / month (injection kit, clinician evaluation, and overnight delivery included)
Sub-Q injection (kit included)
Before you sign up: The advertised “$199” is a first-month promotion — the recurring rate is $249, roughly 2.7× CoreAge's flat $93
- #6
Shed
$169 injection / $144 nasal spray / $169 oral tablets, per one-month supply
Injection (3×/week), nasal spray, oral tablets
Before you sign up: The final price is confirmed inside the patient portal, so the headline is an indication rather than a quote
- #7
MadeMed
No month-to-month plan. Injection $209/mo on a 3-month plan ($627) or $199/mo on 6 months ($1,194); nasal spray $279/mo on 3 months, $269/mo on 6
Sub-Q injection (1,000 mg/mo) + nasal spray
Before you sign up: There is no month-to-month plan at all: the shortest commitment is three months at $627 up front, so the advertised “from $199/mo” is a six-month prepay
From here down: not currently a paid partner — shown for honest comparison, same standard applied
#8AgelessRx
Injection from $185–235/mo; nasal from $125; patch from $160
Injection, nasal spray, transdermal patch
- #9
HydraMed
Injection $299 / month (subscription); $369 one-time
Injection, nasal spray, topical
- #10
Hone Health
Injection $165/mo + $25/mo membership (~$190)
Injection
Before you sign up: Stacked fees — the medication, a consult, and a $25/mo membership add up to roughly $190 vs CoreAge's flat $93
- #11
Invigor Medical
Starting at $340 / month (includes doctor consult and supplies)
Injection + oral
Before you sign up: Starter fee and shifting first-month promotions make the true ongoing cost harder to pin down
Oral NAD+ precursors are absent on purpose — this page is about the needle. They are the only forms with human trial data behind them, and they sit on the main NAD+ board, which also carries the full pros and cons for every provider above.
A clinic drip near you, or a syringe at your kitchen table?
This is the question behind most “NAD+ injections near me” searches, and we are not answering it with a map: we do not run a clinic directory. Here is how the two options genuinely differ — which, outside logistics and money, is less than the marketing suggests.
Clinic IV infusion
- Billed per session. Sessions typically run from roughly one to several hundred dollars each and are often sold in packages, so the real cost depends entirely on how many you buy.
- Someone else administers it. Clinic staff place the line and control the rate — which matters, because NAD+ infused quickly causes transient flushing, nausea and chest or abdominal tightness. That is why a drip is run slowly, and why a session costs you an afternoon.
At-home subcutaneous injection
- Billed per month. The programs above quote a monthly figure, and for most of them the clinician visit, supplies and shipping sit inside it — from $93 a month at the low end to $340 at the high end.
- You administer it. A licensed clinician reviews an online intake and prescribes; the injections are then self-administered, with follow-up by message rather than in a chair.
- The commitment is the catch. A monthly plan is easier to keep paying for than a session is to rebook, and several price their headline on a prepay or a promotional first month.
Now the part that decides it. Neither route has a cognition trial behind it. The only human data on intravenous NAD+ is a small pilot that tracked NAD+ metabolites in plasma and urine through a six-hour infusion and measured no cognitive outcomes whatsoever — we go through it in NAD+ IV for mental clarity. For the subcutaneous injection there is not even that. So the drip is not the “serious” version and the syringe is not the compromise: they are two delivery methods for the same unproven claim, and the only honest basis for choosing is cost and convenience. A monthly plan at the low end above is far cheaper than a package of drips — an argument about price, not about results.
“Before and after”: what you can actually expect
Thousands of people a month go looking for NAD+ injection before-and-afters and find testimonials, clinic galleries and week-one diaries. Here is the answer instead of the gallery: no rigorous human trial shows that injected NAD+ improves cognition, energy or fatigue. There is no before-and-after to report, because the after was never measured under conditions that would separate an effect from an expectation.
That matters more here than in most categories, because of what is being measured. Energy and clarity are self-reported and slippery, the treatment is unmissable — you are giving yourself an injection — and you have just paid a few hundred dollars for it. Each of those lifts a self-rating on its own, and untangling them is exactly what a placebo control is for. Nobody has run one here. The nearest real result is unhelpful for the needle: in the best-controlled cognition trial of an oral NAD+ precursor, blood NAD+ rose and cognition did not move against placebo.
So what can you reasonably expect? A clinician reviewing your intake, a compounded prescription that is not an FDA-approved product, a recurring monthly charge in the range above, and injections you give yourself. On tolerability the record is limited but not alarming — a systematic review found NAD-based interventions generally well tolerated while noting the evidence for benefit is inconsistent. What you should not expect is a measured cognitive change. We would rewrite this page the day a randomized, placebo-controlled trial of subcutaneous NAD+ reports a pre-registered cognition endpoint.
Until then, the full read is in our pillar review, NAD+, brain fog and focus: what the evidence shows, and if it is the drained, can't-think feeling you are trying to fix, the causes worth ruling out first are in NAD+ for cognitive energy and fatigue.
Common questions
What do NAD+ injections actually do?
NAD+ is a coenzyme every cell uses to turn food into usable energy, and a subcutaneous injection puts it into the tissue under the skin rather than through the gut. What happens after that in a person has not been measured properly: there is no randomized, placebo-controlled trial of injected NAD+ reporting a cognition, energy or fatigue outcome. Clinics sell the injection for energy and focus, but that is a marketing claim, not a trial result.
What do NAD+ injections cost?
Among the clinician-supervised programs that publish a figure, month-to-month injection pricing runs from about $161 to $340. Our #1 pick, CoreAge Rx, is a flat $93 a month for either the injection or the nasal spray. Read the ladder carefully: MadeMed sells no single month at all, with a three-month $627 minimum; Enhance MD's advertised $169 is a twelve-month prepay against a $199 month-to-month rate; Sprout Health's $199 is a first-month promotion against a $249 recurring rate; and Hone Health stacks a $25 monthly membership on top of a $165 medication price.
Do NAD+ injections work for energy or focus?
For that specific outcome, nothing has shown that they do. The best-controlled human cognition data in this field is for oral nicotinamide riboside, where blood NAD+ rose and cognition did not improve versus placebo. The only human data on a parenteral route is a small pilot that tracked NAD+ metabolites during a six-hour intravenous infusion and measured no cognitive outcomes at all. For the subcutaneous injection specifically there is no rigorous trial in either direction, so anyone quoting a number for how much sharper you will feel is quoting something that was never measured.
Are NAD+ injections safe, and what are the side effects?
Safety and effectiveness are separate questions, and the safety record here is thinner than it looks. A systematic review found NAD-based interventions generally well tolerated while stressing that the evidence for benefit is inconsistent, and high-dose oral nicotinamide riboside was generally safe in a randomized trial. Infused too quickly, NAD+ causes transient flushing, nausea and chest or abdominal tightness, which is why clinics run a drip over hours. What does not exist is a published characterization of the injectable route's tolerability. Compounded NAD+ is not an FDA-approved product, so ask a clinician before starting, especially if you take other medication.
Injection vs nasal spray vs IV vs oral — which route is better?
Only the oral precursors have human randomized trials, and what those trials show is that they raise blood NAD+ — the ones that also measured thinking found no cognitive benefit. Nasal, intravenous and subcutaneous NAD+ have no cognition trial behind them at all, so no route can be recommended over another on proven results. What the routes genuinely differ on is cost, supervision and convenience: a drip is billed per session in a clinic, an injection or spray is billed per month and self-administered at home, and an oral supplement needs no prescription.
Do you need a prescription for NAD+ injections?
In the United States, yes. Injectable NAD+ is a compounded preparation dispensed by a pharmacy after a licensed clinician reviews your intake, and every provider on this page runs that review before shipping anything. Compounded drugs are not FDA-approved for safety or effectiveness the way a brand-name medicine is. Oral NAD+ precursors such as nicotinamide riboside and NMN are sold as supplements and need no prescription — and they are the only forms with human trial data behind them.
This page is informational and not medical advice. Compounded NAD+ is not an FDA-approved product, and nothing here is approved to treat, cure or prevent any condition. Prices were verified against each provider's own published page and change without notice — check the current figure before you buy, and rule out the ordinary causes of a foggy head before you spend anything at all.